2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

Base Information

Chemical Name:2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester
CAS No.:503186-64-9
Molecular Formula:C₄₀H₅₃NO₆S
Molecular Weight:675.93
Hs Code.:

2-benzyl-8-<i>tert</i>-butoxycarbonylamino-9-(4-<i>tert</i>-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid <i>S</i>-benzyl ester

Synonyms:2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

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Chemical Property of 2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

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Technology Process of 2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

There total 7 articles about 2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 479495-61-9
2-benzyl-3-hydroxy-pent-4-enethioic acid S-benzyl ester

: 503186-55-8
[1-(4-tert-butoxy-2,6-dimethyl-benzyl)-2-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

: 503186-64-9
2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 45 ℃; for 2h;
DOI:10.1021/jm025608s

Reference yield:

: 137650-17-0
1,1-dimethylethyl <2-<4-(1,1-dimethylethoxy)-2,6-dimethylphenyl>-1(S)-formylethyl>carbamate

: 503186-64-9
2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 38 mg / tetrahydrofuran; diethyl ether / 4 h / 0 °C

2: Cl₂(PCy₃)(IMesH₂)RuCHPh / CH₂Cl₂ / 2 h / 45 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/jm025608s

Reference yield:

: 137650-16-9
N-<(1,1-dimethylethoxy)carbonyl>-O-(1,1-dimethylethyl)-2,6-dimethyl-L-tyrosine methyl ester

: 503186-64-9
2-benzyl-8-tert-butoxycarbonylamino-9-(4-tert-butoxy-2,6-dimethyl-phenyl)-3,7-dihydroxy-non-4-enethioic acid S-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: DIBAL-H / toluene; various solvent(s) / 1 h / -78 °C

1.2: Rochelle's salt / toluene; various solvent(s) / 1 h

2.1: 38 mg / tetrahydrofuran; diethyl ether / 4 h / 0 °C

3.1: Cl₂(PCy₃)(IMesH₂)RuCHPh / CH₂Cl₂ / 2 h / 45 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jm025608s