(2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester

Base Information

Chemical Name:(2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester
CAS No.:1313719-66-2
Molecular Formula:C₁₈H₂₀Cl₂N₄O₃S
Molecular Weight:443.354
Hs Code.:

Synonyms:(2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester

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Chemical Property of (2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester

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Technology Process of (2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester

There total 4 articles about (2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.1%

: 1943-83-5
2-chloroethyl isothiocyanate

: 1313719-38-8
4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenylamine

: 1313719-66-2
(2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester

Guidance literature:: In dichloromethane; toluene; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 24795-76-4
2,4,6-trichloro-5-methylthio-pyrimidine

: 1313719-66-2
(2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

3: dichloromethane; toluene / 16 h / 80 °C / Inert atmosphere

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 56035-32-6
5-methylsulfanyl-pyrimidine-2,4,6-trione

: 1313719-66-2
(2-chloroethyl)carbamic acid 4-(4-chloro-5-methylsulfanyl-6-morpholin-4-ylpyrimidin-2-yl)phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 24 h / Reflux

2: tetrahydrofuran / 2 h / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 12 h / 90 °C / Inert atmosphere

4: dichloromethane; toluene / 16 h / 80 °C / Inert atmosphere

With sodium carbonate; N,N-dimethyl-aniline; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;