N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide

Base Information

• Chemical Name: N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide
• CAS No.: 1422128-57-1
• Molecular Formula: C₂₃H₂₆F₆N₄O₂S
• Molecular Weight: 536.541

Synonyms:N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide

Chemical Property of N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide

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Technology Process of N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide

There total 4 articles about N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (1422129-02-9) + N,N-dimethyl-N2-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-D-alaninamide (1422129-98-3) → N2-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide (1422128-57-1)

Guidance literature:

With piperdinium acetate; In isopropyl alcohol; at 60 ℃;

Reference yield:

2,4-bis(trifluoromethyl)benzyl bromide (140690-56-8) → N2-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide (1422128-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / ethanol; N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 1 h / 20 °C

2.1: piperdinium acetate / isopropyl alcohol / 60 °C

With piperdinium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

4-piperidinemethanol (6457-49-4) → N2-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide (1422128-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / ethanol; N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 1 h / 20 °C

2.1: piperdinium acetate / isopropyl alcohol / 60 °C

With piperdinium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

2,4-bis(trifluoromethyl)benzyl bromide

4-piperidinemethanol

1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde

N,N-dimethyl-N²-(2-oxo-2,5-dihydro-1,3-thiazol-4-yl)-D-alaninamide

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