5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide

Base Information

Chemical Name:5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide
CAS No.:1034290-08-8
Molecular Formula:C₈H₁₀O₃S₂
Molecular Weight:218.298
Hs Code.:

Synonyms:5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide

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Chemical Property of 5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide

There total 4 articles about 5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147086-80-4,887130-01-0
5,6-dihydro-(R)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran

: 1034290-08-8,147086-81-5,147128-77-6,162490-45-1
5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide

Guidance literature:: With sodium tungstate; dihydrogen peroxide; In water; ethyl acetate; toluene; 1) 0 - 15 deg C, 30 min, 2) 25 deg C, 2 h;
DOI:10.1021/jo00059a013

Reference yield:

: 147086-79-1
(S)-5,6-dihydro-6-methylthieno<2,3-b>thiopyran-4-one

: 1034290-08-8,147086-81-5,147128-77-6,162490-45-1
5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran; toluene / 0 - 5 °C

2: 24 g / sodium tungstate dihydrate, 30 percent hydrogen peroxide / H₂O; ethyl acetate; toluene / 1) 0 - 15 deg C, 30 min, 2) 25 deg C, 2 h

With sodium tungstate; lithium aluminium tetrahydride; dihydrogen peroxide; In tetrahydrofuran; water; ethyl acetate; toluene;
DOI:10.1021/jo00059a013

Reference yield:

: 133359-80-5
(S)-3-(thien-2-ylthio)butyric acid

: 1034290-08-8,147086-81-5,147128-77-6,162490-45-1
5,6-dihydro-(R,S)-4-hydroxy-(S)-6-methyl-4H-thieno<2,3-b>thiopyran 7,7-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic anhydride / toluene / 1 h / 25 °C

2: LiAlH₄ / tetrahydrofuran; toluene / 0 - 5 °C

3: 24 g / sodium tungstate dihydrate, 30 percent hydrogen peroxide / H₂O; ethyl acetate; toluene / 1) 0 - 15 deg C, 30 min, 2) 25 deg C, 2 h

With sodium tungstate; lithium aluminium tetrahydride; dihydrogen peroxide; trifluoroacetic anhydride; In tetrahydrofuran; water; ethyl acetate; toluene;
DOI:10.1021/jo00059a013