Technology Process of 4-(7-Methyl-1,4-dioxa-spiro[4.5]dec-7-ylmethoxy)-phenylamine
There total 10 articles about 4-(7-Methyl-1,4-dioxa-spiro[4.5]dec-7-ylmethoxy)-phenylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
under 760 Torr;
Ambient temperature;
DOI:10.1248/cpb.32.2267
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 70percent m-chloroperbenzoic acid, NaHCO3 / CHCl3 / 1 h
2: 1.) H2; 2.) Jones reagent / 1.) PtO2 / 1.) AcOH, 50 deg C, 1 atm; 2.) acetone, RT, 30 min
3: p-TsOH / benzene / 3 h / Heating
4: LiAlH4 / diethyl ether / 1 h / Ambient temperature
5: 59.2 percent / NaH / dimethylsulfoxide / 2 h / Ambient temperature
6: H2 / Pd-C / methanol / 760 Torr / Ambient temperature
With
lithium aluminium tetrahydride; jones reagent; hydrogen; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid;
platinum(IV) oxide; palladium on activated charcoal;
In
methanol; diethyl ether; chloroform; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.32.2267
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) H2; 2.) Jones reagent / 1.) PtO2 / 1.) AcOH, 50 deg C, 1 atm; 2.) acetone, RT, 30 min
2: p-TsOH / benzene / 3 h / Heating
3: LiAlH4 / diethyl ether / 1 h / Ambient temperature
4: 59.2 percent / NaH / dimethylsulfoxide / 2 h / Ambient temperature
5: H2 / Pd-C / methanol / 760 Torr / Ambient temperature
With
lithium aluminium tetrahydride; jones reagent; hydrogen; sodium hydride; toluene-4-sulfonic acid;
platinum(IV) oxide; palladium on activated charcoal;
In
methanol; diethyl ether; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.32.2267
