N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

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Chemical Name:N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide
CAS No.:1580494-40-1
Molecular Formula:C₂₆H₃₁FN₄O
Molecular Weight:434.557
Hs Code.:

Synonyms:N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

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Chemical Property of N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

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Technology Process of N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

There total 7 articles about N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1580494-30-9
N,N-diethyl-2-(2-(4-(4-hydroxyhex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

: 1580494-40-1
N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.01.080

Reference yield:

: 619-44-3
methyl 4-iodobenzoate

: 1580494-40-1
N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -65 °C

1.2: 2 h / -65 - -45 °C

2.1: sodium hydroxide / ethanol / 0.25 h

2.2: 96 h / 20 °C

3.1: hydrazine hydrate; acetic acid / ethanol / 80 °C

4.1: ethanol / 5 h / 80 °C

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 24 h / 20 °C

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; hydrazine hydrate; acetic acid; diethylamine; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane; 5.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2014.01.080

Reference yield:

: 206346-33-0
3-(4-iodophenyl)-3-oxopropanenitrile

: 1580494-40-1
N,N-diethyl-2-(2-(4-(6-fluorohex-1-yn-1-yl)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethanol / 0.25 h

1.2: 96 h / 20 °C

2.1: hydrazine hydrate; acetic acid / ethanol / 80 °C

3.1: ethanol / 5 h / 80 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / 24 h / 20 °C

5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrazine hydrate; acetic acid; diethylamine; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In ethanol; dichloromethane; 4.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2014.01.080