5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

Base Information

Chemical Name:5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene
CAS No.:148117-06-0
Molecular Formula:C₂₉H₃₈O₇Si
Molecular Weight:526.702
Hs Code.:

Synonyms:5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

Suppliers and Price of 5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

There total 7 articles about 5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 406214-37-7
8-Benzyloxy-1,4-dimethoxy-6-methoxymethoxy-3,7-dimethyl-naphthalene-2-carboxylic acid

: 148117-06-0
5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1016/0040-4039(93)85004-G

Reference yield: 75.0%

: 148117-07-1
5-benzyloxy-8-bromo-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

: 498578-86-2
(E)-(S)-5-(4-Methoxy-benzyloxy)-2,4-dimethyl-pent-2-enal

: 148117-06-0
5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

: 8-Benzyloxy-5-[(E)-(S)-1-hydroxy-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pent-2-enyl]-1,4-dimethoxy-6-methoxymethoxy-3,7-dimethyl-naphthalene-2-carboxylic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -100 - 0 ℃; for 8h;
DOI:10.1139/cjc-79-11-1711

Reference yield:

: 85954-40-1
3-Bromo-5,7-dihydroxy-2,6-dimethyl-[1,4]naphthoquinone

: 148117-06-0
5-benzyloxy-1,4-dimethoxy-7-methoxymethoxy-2,6-dimethyl-3-[2-(trimethylsilyl)ethoxycarbonyl]naphthalene

Guidance literature:: Multi-step reaction with 5 steps

1.1: P₂O₅ / CHCl₃

2.1: 90 percent / Ag₂O / CHCl₃ / 24 h / 23 °C

3.1: CeCl₃*7H₂O; NaBH₄ / dioxane; H₂O / 0 °C

3.2: 89 percent / 50 percent NaOH / dioxane; H₂O / 1 h / 23 °C

4.1: 90 percent / n-BuLi / tetrahydrofuran / 3 h / -78 - 23 °C

5.1: 85 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 4 h / 23 °C

With sodium tetrahydroborate; n-butyllithium; cerium(III) chloride; phosphorus pentoxide; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; chloroform; water; 5.1: Mitsunobu reaction;
DOI:10.1139/cjc-79-11-1711