tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate

Base Information

• Chemical Name: tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate
• CAS No.: 959119-75-6
• Molecular Formula: C₂₄H₂₉F₃N₂O₄S
• Molecular Weight: 498.566
• Mol file: 959119-75-6.mol

Synonyms:tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate

Chemical Property of tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate

There total 1 articles about tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(trifluoromethyl)sulfonyl]oxy}ethyl)benzoate (959119-73-4) + (1R)-1-phenylprop-2-en-1-amine (325490-29-7) → tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate (959119-75-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 65 ℃; for 16h;

DOI:10.1016/j.bmcl.2007.08.040

Reference yield: 71.0%

C16H22BrNO4 + tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate (959119-75-6) → C40H52F3N3O8S

Guidance literature:

tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(1R)-1-phenylprop-2-en-1-yl]amino}ethyl)benzoate; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 75 ℃; for 1h;

C₁₆H₂₂BrNO₄; With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene; at 85 ℃; for 16h; Further stages.;

DOI:10.1016/j.bmcl.2007.08.040

upstream raw materials:

tert-butyl 3-[methyl(methylsulfonyl)amino]-5-(2,2,2-trifluoro-1-{[(trifluoromethyl)sulfonyl]oxy}ethyl)benzoate

(1R)-1-phenylprop-2-en-1-amine