THIAZOLE, 4-(BROMOMETHYL)-2-METHYL-

Base Information

• Chemical Name: THIAZOLE, 4-(BROMOMETHYL)-2-METHYL-
• CAS No.: 74704-39-5
• Molecular Formula: C5H6 Br N S
• Molecular Weight: 192.079
• Hs Code.: 2934100090
• Mol file: 74704-39-5.mol

Synonyms:(2-Methylthiazol-4-yl)methylbromide; 2-Methyl-4-bromomethylthiazole; 4-Bromomethyl-2-methylthiazole

Chemical Property of THIAZOLE, 4-(BROMOMETHYL)-2-METHYL-

Chemical Property:

• Vapor Pressure: 0.0966mmHg at 25°C
• Refractive Index: 1.597
• Boiling Point: 231°C at 760 mmHg
• PKA: 1.17±0.10(Predicted)
• Flash Point: 93.5°C
• PSA: 41.13000
• Density: 1.629g/cm³
• LogP: 2.34640
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98% ^*data from raw suppliers

4-(Bromomethyl)-2-methylthiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THIAZOLE, 4-(BROMOMETHYL)-2-METHYL-

There total 1 articles about THIAZOLE, 4-(BROMOMETHYL)-2-METHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-methylthiazole-4-carboxylate (6436-59-5) → 4-(bromomethyl)-2-methyl-1,3-thiazole (74704-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / LiAlH₄ / diethyl ether / 3 h / -78 °C

2: 85 percent / Ph₃P; CBr₄ / CCl₄ / 3 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In tetrachloromethane; diethyl ether;

DOI:10.1021/jo048742o

Reference yield:

4-(bromomethyl)-2-methyl-1,3-thiazole (74704-39-5) → epothilone B (152044-54-7)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 86 percent / 3 h / 160 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 86 percent / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

3.1: (1R)-(+)-pinene; BH₃*DMS / tetrahydrofuran / 0.5 h / 20 °C

3.2: 78 percent / lithium hydroxide; sodium perborate / tetrahydrofuran; H₂O / 2 h / 20 °C

4.1: 94 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

5.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.25 h / -78 - -40 °C

5.2: 59 percent / ZnCl₂ / tetrahydrofuran; hexane; diethyl ether / 0.25 h / -78 °C

6.1: pyridine / CH₂Cl₂ / 1 h / 0 °C

7.1: CH₂Cl₂ / 5 h / 20 °C

8.1: 0.67 g / acetic acid / tetrahydrofuran; H₂O / 3 h / 0 °C

9.1: 72 percent / magnesium bromide; nitromethane; 1-butanethiol / diethyl ether / 1 h / 20 °C

10.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C

10.2: 0.14 g / DMAP / toluene; tetrahydrofuran / 4 h / 20 °C

11.1: 92 percent / zinc; ammonium chloride / methanol / 0.33 h / Heating

12.1: 95 percent / hydrogen fluoride-pyridine / tetrahydrofuran / 16 h / 20 °C

13.1: 30 percent / m-CPBA / CHCl₃ / 5 h / -10 - 0 °C

With pyridine; n-butyllithium; oxalyl dichloride; nitromethane; n-butanethiol; dimethylsulfide borane complex; (1R)-(+)-pinene; 2,4,6-trichlorobenzoyl chloride; ammonium chloride; pyridine hydrogenfluoride; acetic acid; dimethyl sulfoxide; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; magnesium bromide; zinc; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; water; 2.2: Wadsworth-Horner-Emmons reaction / 4.1: Swern oxidation / 10.2: Yamaguchi macrolactonization;

DOI:10.1021/jo048742o

Reference yield:

4-(bromomethyl)-2-methyl-1,3-thiazole (74704-39-5) → epothilone D (189453-10-9)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 86 percent / 3 h / 160 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 86 percent / tetrahydrofuran; hexane / 12 h / -78 - 20 °C

3.1: (1R)-(+)-pinene; BH₃*DMS / tetrahydrofuran / 0.5 h / 20 °C

3.2: 78 percent / lithium hydroxide; sodium perborate / tetrahydrofuran; H₂O / 2 h / 20 °C

4.1: 94 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

5.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1.25 h / -78 - -40 °C

5.2: 59 percent / ZnCl₂ / tetrahydrofuran; hexane; diethyl ether / 0.25 h / -78 °C

6.1: pyridine / CH₂Cl₂ / 1 h / 0 °C

7.1: CH₂Cl₂ / 5 h / 20 °C

8.1: 0.67 g / acetic acid / tetrahydrofuran; H₂O / 3 h / 0 °C

9.1: 72 percent / magnesium bromide; nitromethane; 1-butanethiol / diethyl ether / 1 h / 20 °C

10.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 1 h / 0 °C

10.2: 0.14 g / DMAP / toluene; tetrahydrofuran / 4 h / 20 °C

11.1: 92 percent / zinc; ammonium chloride / methanol / 0.33 h / Heating

12.1: 95 percent / hydrogen fluoride-pyridine / tetrahydrofuran / 16 h / 20 °C

With pyridine; n-butyllithium; oxalyl dichloride; nitromethane; n-butanethiol; dimethylsulfide borane complex; (1R)-(+)-pinene; 2,4,6-trichlorobenzoyl chloride; ammonium chloride; pyridine hydrogenfluoride; acetic acid; dimethyl sulfoxide; triethylamine; diisopropylamine; magnesium bromide; zinc; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; 2.2: Wadsworth-Horner-Emmons reaction / 4.1: Swern oxidation / 10.2: Yamaguchi macrolactonization;

DOI:10.1021/jo048742o

upstream raw materials:

ethyl 2-methylthiazole-4-carboxylate

Downstream raw materials:

epothilone B

epothilone D

4-((1-(4-fluorophenyl)hydrazinyl)methyl)-2-methylthiazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 74704-39-5 THIAZOLE, 4-(BROMOMETHYL)-2-METHYL-

Send

Send

Metric Ton KG G Pound L ML

Send

Send