3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate

Base Information

Chemical Name:3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate
CAS No.:1600566-33-3
Molecular Formula:C₂HF₃O₂*C₂₉H₁₇ClF₆N₂O₂
Molecular Weight:688.934
Hs Code.:

Synonyms:3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate

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Chemical Property of 3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate

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Technology Process of 3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate

There total 5 articles about 3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1600566-31-1
(3-chlorophenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 1600566-33-3
3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate

Guidance literature:: (3-chlorophenyl)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)(pyridin-3-yl)methanol trifluoroacetate; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 40 ℃; for 1h;

trifluoroacetic acid; In acetonitrile;

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1600566-33-3
3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.1 h / -68 °C / Inert atmosphere; Cooling with acetone-dry ice

1.2: Inert atmosphere

2.1: sodium azide / dimethyl sulfoxide / 1 h / 95 °C

2.2: 0.5 h / 20 °C

3.1: tributyl-amine / N,N-dimethyl-formamide / 2 h / 130 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / -71 °C / Inert atmosphere

4.2: Inert atmosphere

4.3: Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 40 °C

With n-butyllithium; sodium azide; tributyl-amine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 617706-15-7
1-(5-bromo-2-fluorophenyl)-2,2,2-trifluoro-ethanone

: 1600566-33-3
3-((3-chlorophenyl)(hydroxy)(3-phenyl-2,4-bis(trifluoromethyl)quinolin-6-yl)methyl)pyridine-1-oxide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / dimethyl sulfoxide / 1 h / 95 °C

1.2: 0.5 h / 20 °C

2.1: tributyl-amine / N,N-dimethyl-formamide / 2 h / 130 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / -71 °C / Inert atmosphere

3.2: Inert atmosphere

3.3: Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 40 °C

With n-butyllithium; sodium azide; tributyl-amine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;