(S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline

Base Information

Chemical Name:(S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline
CAS No.:172757-26-5
Molecular Formula:C₁₉H₂₁NO₄S
Molecular Weight:359.446
Hs Code.:

Synonyms:(S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of (S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline

There total 5 articles about (S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 172757-21-0
N-(2,2-Dimethoxy-ethyl)-N-[(S)-1-(3,4-dimethoxy-phenyl)-ethyl]-4-methyl-benzenesulfonamide

: 172757-26-5
(S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; Heating;
DOI:10.1016/0040-4039(95)01975-N

Reference yield:

: 54771-60-7
4-acetyl-2-methoxyphenyl acetate

: 172757-26-5
(S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: BH₃*SMe₂, 10percent mol oxazaborolidine derivative / tetrahydrofuran / 6 h / -20 °C

2: 60 percent / PPh₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 3 h / Ambient temperature

3: 95 percent / piperidine / ethanol; diethyl ether / 48 h / Ambient temperature

4: 80 percent / 6N HCl / dioxane / Heating

With piperidine; hydrogenchloride; dimethylsulfide borane complex; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol;
DOI:10.1016/0040-4039(95)01975-N

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 172757-26-5
(S)-6,7-Dimethoxy-1-methyl-2-(toluene-4-sulfonyl)-1,2-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / pyridine / CH₂Cl₂ / Ambient temperature

2: BH₃*SMe₂, 10percent mol oxazaborolidine derivative / tetrahydrofuran / 6 h / -20 °C

3: 60 percent / PPh₃, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 3 h / Ambient temperature

4: 95 percent / piperidine / ethanol; diethyl ether / 48 h / Ambient temperature

5: 80 percent / 6N HCl / dioxane / Heating

With piperidine; pyridine; hydrogenchloride; dimethylsulfide borane complex; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/0040-4039(95)01975-N