4-(Butan-2-yl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(Butan-2-yl)-1,3-thiazol-2-amine
• CAS No.: 79932-24-4
• Molecular Formula: C₇H₁₂N₂S
• Molecular Weight: 156.252
• DSSTox Substance ID: DTXSID101300371
• Mol file: 79932-24-4.mol

Synonyms:4-(butan-2-yl)-1,3-thiazol-2-amine;79932-24-4;4-(sec-Butyl)thiazol-2-amine;4-butan-2-yl-1,3-thiazol-2-amine;2-Amino-4-(2-butyl)thiazole;SCHEMBL10988006;UZWADJYISZVARR-UHFFFAOYSA-N;DTXSID101300371;4-(1-Methylpropyl)-2-thiazolamine;AKOS006026250;2-Thiazolamine, 4-(1-methylpropyl)-;EN300-67058;G24017;Z608067116

Chemical Property of 4-(Butan-2-yl)-1,3-thiazol-2-amine

Chemical Property:

• Boiling Point: 10.9-11 °C(Press: 2 Torr)
• PKA: 5.47±0.10(Predicted)
• PSA: 67.15000
• Density: 1.108±0.06 g/cm3(Predicted)
• LogP: 2.82000
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 156.07211956
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

4-(butan-2-yl)-1,3-thiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)C1=CSC(=N1)N

Technology Process of 4-(Butan-2-yl)-1,3-thiazol-2-amine

There total 4 articles about 4-(Butan-2-yl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous potassium hydroxide + 1-bromo-3-methylpentan-2-one (79932-23-3) → 4-sec-butyl-thiazol-2-ylamine (79932-24-4)

Guidance literature:

With thiourea; In ethanol;

Reference yield:

iso-butyl chloroformate (5856-79-1,57526-28-0) → 4-sec-butyl-thiazol-2-ylamine (79932-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: ethanol / 1 h / Heating

In diethyl ether; ethanol;

Reference yield:

1-diazo-3-methyl-pentan-2-one (80524-86-3) + thiourea (17356-08-0) → 4-sec-butyl-thiazol-2-ylamine (79932-24-4)

Guidance literature:

In ethanol; for 1h; Heating;

upstream raw materials:

1-diazo-3-methyl-pentan-2-one

thiourea

iso-butyl chloroformate

1-bromo-3-methylpentan-2-one