3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide
CAS No.:949524-37-2
Molecular Formula:C₂₇H₂₄F₂N₂O₂
Molecular Weight:446.497
Hs Code.:

Synonyms:3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Suppliers and Price of 3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

There total 10 articles about 3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027038-69-2
C₂₁H₁₆ClF₂NO₂

: 949524-37-2
3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 3.61 g / triethylamine / CH₂Cl₂ / 12 h / 25 °C

2: 47 percent / NaBH₄ / methanol / 1 h / 0 - 25 °C

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.tet.2007.06.005

Reference yield:

: 855248-38-3
3,4-bis-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid

: 949524-37-2
3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 1 h / 70 °C

2: 3.61 g / triethylamine / CH₂Cl₂ / 12 h / 25 °C

3: 47 percent / NaBH₄ / methanol / 1 h / 0 - 25 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.tet.2007.06.005

Reference yield:

: 126209-32-3
3,4-bis-(4-fluorophenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

: 949524-37-2
3,4-bis(4-fluoro-phenyl)-5-(hydroxymethyl)-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / KOH / dimethylsulfoxide / 1.5 h / 25 °C

2: 45 percent / phosphorus oxychloride / 1,2-dichloro-ethane / 3 h / 80 °C

3: 100 percent / aq. sodium hydroxide / methanol / 2 h / 60 °C

4: thionyl chloride / 1 h / 70 °C

5: 3.61 g / triethylamine / CH₂Cl₂ / 12 h / 25 °C

6: 47 percent / NaBH₄ / methanol / 1 h / 0 - 25 °C

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; triethylamine; trichlorophosphate; In methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; 2: Vilsmeier-Haack reaction;
DOI:10.1016/j.tet.2007.06.005