1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:192652-86-1
Molecular Formula:C₄₃H₄₈N₂O₆Si
Molecular Weight:716.949
Hs Code.:

1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

There total 1 articles about 1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 88023-78-3
para-methoxybenzyl chloride

: 161168-94-1
1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-styryl-β-D-erythro-pentofuranosyl>thymine

: 192652-86-1
1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 ℃; for 1h;
DOI:10.1016/S0960-894X(97)00270-9

Reference yield: 100.0%

: 192652-86-1
1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

: 192652-87-2
1-[(2R,4R,5S)-5-Hydroxymethyl-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/S0960-894X(97)00270-9

Reference yield:

: 192652-86-1
1-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-3-(4-methoxy-benzyloxymethyl)-5-methyl-1H-pyrimidine-2,4-dione

: 192652-90-7
(2S,3S,5R)-2-Benzyloxymethyl-5-[3-(4-methoxy-benzyloxymethyl)-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-tetrahydro-furan-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Bu₄NF / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: 99 percent / NaH, Bu₄NI / tetrahydrofuran / 36 h / 0 - 20 °C

3: 93 percent / OsO₄, NMO / acetone; H₂O / 0.5 h / Ambient temperature

4: 100 percent / NaIO₄ / dioxane; H₂O / 2 h

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; 1,4-dioxane; water; acetone;
DOI:10.1016/S0960-894X(97)00270-9