N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

Base Information

Chemical Name:N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide
CAS No.:1026382-25-1
Molecular Formula:C₃₄H₄₂N₄O₃
Molecular Weight:554.732
Hs Code.:

<i>N</i>-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

Synonyms:N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

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Chemical Property of N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

Chemical Property:

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Technology Process of N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

There total 5 articles about N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026269-96-4
3-({3-[4-(3,3,3-triphenyl-propionylamino)-butyrylamino]-propionylamino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1026382-25-1
N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃;
DOI:10.1021/jm010480k

Reference yield:

: 3-(4-amino-butyrylamino)-propionic acid methyl ester

: 1026382-25-1
N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: WSC; HOBt; NEt₃ / CHCl₃ / 20 °C

2: 4N aq. NaOH / methanol; CHCl₃ / 20 °C

3: WSC; HOBt / CHCl₃ / 20 °C

4: TFA / CHCl₃ / 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In methanol; chloroform;
DOI:10.1021/jm010480k

Reference yield:

: 3-(4-tert-butoxycarbonylamino-butyrylamino)-propionic acid methyl ester

: 1026382-25-1
N-{2-[(piperidin-3-ylmethyl)-carbamoyl]-ethyl}-4-(3,3,3-triphenyl-propionylamino)-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 10percent HCl / methanol

2: WSC; HOBt; NEt₃ / CHCl₃ / 20 °C

3: 4N aq. NaOH / methanol; CHCl₃ / 20 °C

4: WSC; HOBt / CHCl₃ / 20 °C

5: TFA / CHCl₃ / 20 °C

With sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In methanol; chloroform;
DOI:10.1021/jm010480k