(+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane

Base Information

Chemical Name:(+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane
CAS No.:863555-45-7
Molecular Formula:C₁₉H₃₃N₃
Molecular Weight:303.491
Hs Code.:

Synonyms:(+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane

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Chemical Property of (+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane

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Technology Process of (+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane

There total 6 articles about (+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: H-L-Phe-L-Leu-N-pyrrolidinyl

: 863555-45-7
(+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 48h; Heating;
DOI:10.1021/ja053368a

Reference yield:

: 863555-42-4
Boc-L-Phe-L-Leu-N-pyrrolidinyl

: 863555-45-7
(+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane

Guidance literature:: Multi-step reaction with 2 steps

1: AcCl; MeOH / 6 h / 0 - 20 °C

2: LiAlH₄ / tetrahydrofuran / 48 h / Heating

With methanol; lithium aluminium tetrahydride; acetyl chloride; In tetrahydrofuran;
DOI:10.1021/ja053368a

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 863555-45-7
(+)-(2S,2'S)-2-amino-1-{N-[4'-methyl-1'-(pyrrolidin-1''-yl)pentan-2'-yl]amino}-3-phenylpropane

Guidance literature:: Multi-step reaction with 5 steps

1: 1-hydroxybenzotriazole; 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride; i-Pr₂NEt / tetrahydrofuran / 12.5 h / 0 - 20 °C

2: AcCl; MeOH / 4 h / 0 - 20 °C

3: 1-hydroxybenzotriazole; 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride; i-Pr₂NEt / tetrahydrofuran / 12.5 h / 0 - 20 °C

4: AcCl; MeOH / 6 h / 0 - 20 °C

5: LiAlH₄ / tetrahydrofuran / 48 h / Heating

With methanol; lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; In tetrahydrofuran;
DOI:10.1021/ja053368a