Dilacor XR

Base Information

Chemical Name:Dilacor XR
CAS No.:34933-06-7
Molecular Formula:C22H26 N2 O4 S
Molecular Weight:414.525
Hs Code.:
European Community (EC) Number:260-060-0,252-295-2
DSSTox Substance ID:DTXSID50881104
Nikkaji Number:J221.636A
Wikidata:Q27156381
Pharos Ligand ID:CV8H86H77NN6
ChEMBL ID:CHEMBL603584
Mol file:34933-06-7.mol

Synonyms:Aldizem;Cardil;Cardizem;CRD 401;CRD-401;CRD401;Dilacor;Dilacor XR;Dilren;Diltiazem;Diltiazem Hydrochloride;Diltiazem Malate;Dilzem;Tiazac

Suppliers and Price of Dilacor XR

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3-ACETOXY-5-[2-(DIMETHYLAMINO)ETHYL]-2,3-DIHYDRO-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE 95.00%
5MG
$ 495.43

Total 8 raw suppliers

Chemical Property of Dilacor XR

Chemical Property:

Vapor Pressure:4.27E-14mmHg at 25°C
Boiling Point:594.4°Cat760mmHg
Flash Point:313.3°C
PSA：84.38000
Density:1.26g/cm³
LogP:3.43350
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:414.16132849
Heavy Atom Count:29
Complexity:565

Purity/Quality:

99% ^*data from raw suppliers

3-ACETOXY-5-[2-(DIMETHYLAMINO)ETHYL]-2,3-DIHYDRO-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC

Technology Process of Dilacor XR

There total 12 articles about Dilacor XR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 34933-06-7
diltiazem

Guidance literature:

Reference yield:

: 154076-93-4
ethyl (Z)-2-(2-methoxyethoxy)methoxy-3-(4-methoxyphenyl)-2-propenoate

: 34933-06-7,42399-41-7,56209-45-1,75472-92-3,84675-89-8,84675-91-2,85100-18-1,111188-70-6,111188-71-7
(+/-)-Diltiazem

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent Spectr_. / BuLi / tetrahydrofuran / 5 h / 70 °C

2: 5percent aq. NaOH / Ambient temperature

3: 7 percent / 4 Angstroem molecular sieves / xylene / Heating

4: K₂CO₃

With sodium hydroxide; n-butyllithium; 4 A molecular sieve; potassium carbonate; In tetrahydrofuran; xylene;
DOI:10.1016/S0040-4020(01)88031-5

Reference yield:

: 3-Hydroxy-2-(2-methoxy-ethoxymethoxy)-3-(4-methoxy-phenyl)-propionic acid ethyl ester

: 34933-06-7,42399-41-7,56209-45-1,75472-92-3,84675-89-8,84675-91-2,85100-18-1,111188-70-6,111188-71-7
(+/-)-Diltiazem

Guidance literature:: Multi-step reaction with 6 steps

1: 49 percent / Et₃N, 2-fluoro-1-methylpyridinium p-toluenesulfonate / CH₂Cl₂ / 2 h / Ambient temperature

2: 85 percent Spectr_. / BuLi / tetrahydrofuran / 5 h / 70 °C

3: 5percent aq. NaOH / Ambient temperature

4: 7 percent / 4 Angstroem molecular sieves / xylene / Heating

5: K₂CO₃

With sodium hydroxide; n-butyllithium; 4 A molecular sieve; potassium carbonate; 1-methyl-2-fluoropyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; dichloromethane; xylene;
DOI:10.1016/S0040-4020(01)88031-5