6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid

Base Information

Chemical Name:6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid
CAS No.:1467058-91-8
Molecular Formula:C₁₈H₁₆ClNO₄
Molecular Weight:345.782
Hs Code.:

Synonyms:6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid

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Chemical Property of 6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid

Chemical Property:

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Technology Process of 6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid

There total 4 articles about 6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1467061-41-1
6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carbaldehyde

: 1467058-91-8
6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; In tetrahydrofuran; water; tert-butyl alcohol; at 30 ℃; for 3h;

Reference yield:

: C₁₄H₁₅BClNO₃

: 1467058-91-8
6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate / water; tert-butyl alcohol; tetrahydrofuran / 3 h / 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 122531-09-3
5-bromo-6-chloro-1H-indole

: 1467058-91-8
6-chloro-5-[4-(2-hydroxyethyl)-3-methoxyphenyl]-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dimethyl sulfoxide / 1 h / 100 °C

2: N,N-dimethyl(methylene)ammonium chloride / 1,4-dioxane / 0.17 h / 20 °C / Sealed tube

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

4: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate / water; tert-butyl alcohol; tetrahydrofuran / 3 h / 30 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate; 2-methyl-but-2-ene; N,N-dimethyl(methylene)ammonium chloride; potassium acetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;