N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide

Base Information

Chemical Name:N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide
CAS No.:1350454-83-9
Molecular Formula:C₂₇H₂₀F₆N₆O₂S
Molecular Weight:606.551
Hs Code.:

Synonyms:N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide

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Chemical Property of N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide

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Technology Process of N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide

There total 6 articles about N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.5%

: 6-(3-methoxyphenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 205117-28-8
C₁₁H₁₀F₆N₂O

: 1350454-83-9
N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80 ℃; for 8h;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 5000-65-7
2-bromo-3'-methoxyacetophenone

: 1350454-83-9
N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 16 h / Reflux

2: palladium diacetate; caesium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 12 h / 80 °C

3: Oxone / methanol; water / 16 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With Oxone; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

: 815596-13-5
6-(3-Methoxyphenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

: 1350454-83-9
N-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3,5-bis(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: Oxone / methanol; water / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With Oxone; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.08.024