(5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Base Information

Chemical Name:(5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone
CAS No.:1260527-51-2
Molecular Formula:C₂₄H₂₅ClN₄OS
Molecular Weight:453.008
Hs Code.:

Synonyms:(5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

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Chemical Property of (5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

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Technology Process of (5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

There total 5 articles about (5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260527-42-1
(+/-)-(5-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

: 1260527-51-2
(5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

: 1260527-52-3
(5(S)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: With Column Phenomenex LUX 5u cellulose-1, AXIA; In ethanol; hexane; diethylamine;

Reference yield:

: 1260527-32-9
6-azaspiro[2.5]octane hydrobromide

: 1260527-51-2
(5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

: 1260527-52-3
(5(S)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 18.3 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / hexane; diethyl ether / -60 - 20 °C

2.2: 0.5 h / -78 °C

3.1: acetic acid / 1,1-dichloroethane / 3 h / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid / 18 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C

6.2: 18 h / 20 °C

7.1: DEA; Phenomenex LUX 5u cellulose-Phenomenex LUX 5u cellulose-DEA; Phenomenex LUX 5u cellulose-1 / hexane; ethanol / Resolution of racemate

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In diethyl ether; 1,1-dichloroethane; ethanol; hexane; dichloromethane; acetic acid;

Reference yield:

: C₁₈H₂₄ClN₃O₂

: 1260527-51-2
(5(R)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

: 1260527-52-3
(5(S)-((5-chloropyridin-2-ylamino)methyl)-6-azaspiro[2.5]octan-6-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; acetic acid / 18 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: DEA; Phenomenex LUX 5u cellulose-Phenomenex LUX 5u cellulose-DEA; Phenomenex LUX 5u cellulose-1 / hexane; ethanol / Resolution of racemate

With sodium tris(acetoxy)borohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,1-dichloroethane; ethanol; hexane; dichloromethane; acetic acid;