(1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

Base Information

Chemical Name:(1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol
CAS No.:259801-07-5
Molecular Formula:C₃₈H₃₄O₅S₃
Molecular Weight:666.883
Hs Code.:

Synonyms:(1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

Suppliers and Price of (1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

There total 6 articles about (1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 259801-06-4
(1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

: 259801-07-5
(1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane; at 20 ℃; for 6h;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2160::AID-HLCA2160>3.0.CO;2-4

Reference yield:

: 3480-11-3
5-bromo(2,2'-bithiophene)

: 259801-07-5
(1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Mg / I₂ / tetrahydrofuran / 2 h / Heating

1.2: 39 percent / [PdCl₂(dppf)2] / tetrahydrofuran; CH₂Cl₂ / 16 h / -20 - 20 °C

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 2 h / 50 °C

2.2: CdCl₂ / tetrahydrofuran / 2 h / Heating

2.3: 55 percent / tetrahydrofuran / 16 h / 20 °C

3.1: 72 percent / NaOMe / methanol; CH₂Cl₂ / 4 h / 20 °C

4.1: 91 percent / iPr₂EtN; 4-(dimethylamino)pyridine / pyridine; CH₂Cl₂ / 6 h / 20 °C

With dmap; sodium methylate; magnesium; ethylene dibromide; N-ethyl-N,N-diisopropylamine; iodine; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1.1: Grignard reaction / 1.2: Arylation / 2.1: Grignard reaction / 2.2: Metallation / 2.3: Arylation / 3.1: Deacylation / 4.1: Etherification;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2160::AID-HLCA2160>3.0.CO;2-4

Reference yield:

: 3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3
Hoffer's chlorosugar

: 259801-07-5
(1S)-1,4-anhydro-1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-1-([2,2':5',2''-terthiophen]-5-yl)-D-erythro-pentitol

Guidance literature:: Multi-step reaction with 3 steps

1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 2 h / 50 °C

1.2: CdCl₂ / tetrahydrofuran / 2 h / Heating

1.3: 55 percent / tetrahydrofuran / 16 h / 20 °C

2.1: 72 percent / NaOMe / methanol; CH₂Cl₂ / 4 h / 20 °C

3.1: 91 percent / iPr₂EtN; 4-(dimethylamino)pyridine / pyridine; CH₂Cl₂ / 6 h / 20 °C

With dmap; sodium methylate; magnesium; ethylene dibromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1.1: Grignard reaction / 1.2: Metallation / 1.3: Arylation / 2.1: Deacylation / 3.1: Etherification;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2160::AID-HLCA2160>3.0.CO;2-4