(3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone

Base Information

• Chemical Name: (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone
• CAS No.: 459870-98-5
• Molecular Formula: C₁₉H₃₀O₄Si
• Molecular Weight: 350.53
• Mol file: 459870-98-5.mol

Synonyms:(3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone

Chemical Property of (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone

There total 9 articles about (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.3%

(R)-1-phenylethanol (1517-69-7) + 3-(tert-butyl-dimethyl-silanyloxy)-pentanedial (459870-95-2) → (3S,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone + (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone (459870-98-5)

Guidance literature:

(R)-1-phenylethanol; 3-(tert-butyl-dimethyl-silanyloxy)-pentanedial; for 24h; Molecular sieve; Inert atmosphere;

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 18h; Molecular sieve; Inert atmosphere;

DOI:10.1016/j.tet.2015.08.010

Reference yield:

C19H32O4Si → (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone (459870-98-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 18h; Molecular sieve;

DOI:10.1016/j.bmc.2015.04.048

Reference yield:

C19H32O4Si → (3S,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone + (3R,5S,1'R)-3-(t-butyldimethylsilyloxy)-5-hydroxy-5-(1'-phenylethoxy) pentanoic acid lactone (459870-98-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 18h; Molecular sieve;

DOI:10.1016/j.bmc.2015.04.048

upstream raw materials:

(R)-1-phenylethanol

3-(tert-butyl-dimethyl-silanyloxy)-pentanedial

4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2,6-diol

1, 6-heptadien-4-ol