1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol

Base Information

Chemical Name:1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol
CAS No.:1026948-42-4
Molecular Formula:C₂₀H₁₉F₂N₃O₃S
Molecular Weight:419.452
Hs Code.:

Synonyms:1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol

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Chemical Property of 1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol

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Technology Process of 1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol

There total 7 articles about 1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1635-61-6
5-chloro-2-nitroaniline

: 1026948-42-4
1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

6: tetrahydrofuran; diethyl ether; toluene / 2 h

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; nickel; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 69584-87-8
2,5-difluorophenylacetonitrile

: 1026948-42-4
1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: t-BuOK / dimethylformamide / 4 h / Ambient temperature

2: 30percent aq. H₂O₂ / dimethylformamide / 0 - 20 °C

3: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

4: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

5: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

6: tetrahydrofuran; diethyl ether; toluene / 2 h

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; dihydrogen peroxide; nickel; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm970423k

Reference yield:

: 1026824-06-5
(3-Amino-4-nitro-phenyl)-(2,5-difluoro-phenyl)-methanone

: 1026948-42-4
1-[2-Amino-3-(propane-2-sulfonyl)-3H-benzoimidazol-5-yl]-1-(2,5-difluoro-phenyl)-but-3-yn-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Raney nickel / tetrahydrofuran / 12 h / 3102.9 Torr

2: pyridine / CH₂Cl₂ / 5 h / Ambient temperature

3: 2N aq. NaOH / propan-2-ol; acetonitrile / Ambient temperature

4: tetrahydrofuran; diethyl ether; toluene / 2 h

With pyridine; sodium hydroxide; hydrogen; nickel; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; toluene; acetonitrile;
DOI:10.1021/jm970423k