[(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde

Base Information

• Chemical Name: [(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde
• CAS No.: 121352-96-3
• Molecular Formula: C₁₉H₂₈O₄
• Molecular Weight: 320.429
• Mol file: 121352-96-3.mol

Synonyms:[(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde

Chemical Property of [(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde

There total 22 articles about [(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<(4R,6S)-6-(2-benzyloxy-1,1-dimethylethyl)-2,2-dimethyl-1,3-dioxan-4-yl>ethanol (121352-95-2) → [(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde (121352-96-3)

Guidance literature:

With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -78 ℃; for 1h;

DOI:10.1021/jo00273a009

Reference yield:

3-[(4S,6R)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-propane-1,2-diol → [(4R,6R)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde (121352-96-3)

Guidance literature:

With sodium periodate; 4-methylmorpholine N-oxide; In acetone; tert-butyl alcohol; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2006.05.077

Reference yield:

(4S,6R)-4-Allyl-6-(2-benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxane (202406-58-4) → [(4R,6R)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetaldehyde (121352-96-3)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; Multistep reaction; 1.) acetone, tBuOH, r.t.; 2.) H₂O, r.t.;

DOI:10.1246/cl.1998.85

upstream raw materials:

2-<(4R,6S)-6-(2-benzyloxy-1,1-dimethylethyl)-2,2-dimethyl-1,3-dioxan-4-yl>ethanol

5,5-dimethyl-2-phenyl-[1,3]dioxane

3-(benzyloxy)-2,2-dimethylpropan-1-ol

3-benzyloxypivalic aldehyde

Downstream raw materials:

(E)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-but-2-enoic acid methyl ester

(E)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-but-2-en-1-ol

(S)-4-[(4R,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-butane-1,3-diol

{(2R,3R)-3-[(4S,6S)-6-(2-Benzyloxy-1,1-dimethyl-ethyl)-2,2-dimethyl-[1,3]dioxan-4-ylmethyl]-oxiranyl}-methanol