3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester

Base Information

• Chemical Name: 3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester
• CAS No.: 918964-88-2
• Molecular Formula: C₂₆H₃₄N₂O₅
• Molecular Weight: 454.566
• Mol file: 918964-88-2.mol

Synonyms:3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester

Chemical Property of 3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester

There total 2 articles about 3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-fluorocarbonyl-1-methyl-ethyl)-carbamic acid tert-butyl ester (918964-78-0) + benzyl-(S)-3-amino-4-phenylbutanoate trifluoroacetic acid salt → 3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester (918964-88-2)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 90 ℃; for 0.05h;

DOI:10.1002/anie.200602167

Reference yield:

(R)-3-((tert-butoxycarbonyl)amino)butanoic acid (159991-23-8) → 3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester (918964-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; cyanuric fluoride / CH₂Cl₂ / 3 h / 20 °C

2: N-methylmorpholine / dimethylformamide / 0.05 h / 90 °C

With 4-methyl-morpholine; pyridine; trifluoro-[1,3,5]triazine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.200602167

Reference yield:

3-(3-tert-butoxycarbonylamino-butyrylamino)-4-phenyl-butyric acid benzyl ester (918964-88-2) + trifluoroacetic acid (76-05-1) → 3-(3-amino-butyrylamino)-4-phenyl-butyric acid benzyl ester; compound with trifluoro-acetic acid

Guidance literature:

at 0 - 20 ℃; for 2h;

DOI:10.1002/anie.200602167

upstream raw materials:

(2-fluorocarbonyl-1-methyl-ethyl)-carbamic acid tert-butyl ester

(R)-3-((tert-butoxycarbonyl)amino)butanoic acid