(S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

Base Information

Chemical Name:(S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate
CAS No.:1351184-96-7
Molecular Formula:C₃₇H₄₄N₂O₃Si
Molecular Weight:592.853
Hs Code.:

Synonyms:(S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

Suppliers and Price of (S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

There total 5 articles about (S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1185007-39-9
5-(bromomethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-pyridine

: 1351184-94-5
2-phenylpropan-2-yl-2-((diphenylmethylene)amino)acetate

: 1351184-96-7
(S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

Guidance literature:: 5-(bromomethyl)-2-(((tert-butyldimethylsilyl)oxy)methyl)-pyridine; 2-phenylpropan-2-yl-2-((diphenylmethylene)amino)acetate; With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; In chloroform; toluene; for 0.05h; Cooling;

With cesiumhydroxide monohydrate; In chloroform; toluene; optical yield given as %ee; enantioselective reaction; Cooling;
DOI:10.1021/ol202939g

Reference yield:

: bromoacetic acid 1-methyl-1-phenylethyl ester

: 1351184-96-7
(S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / Inert atmosphere

2.1: Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾ / chloroform; toluene / 0.05 h / Cooling

2.2: Cooling

With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; N-ethyl-N,N-diisopropylamine; In chloroform; toluene; acetonitrile;
DOI:10.1021/ol202939g

Reference yield:

: 617-94-7
1-methyl-1-phenylethyl alcohol

: 1351184-96-7
(S)-2-phenylpropan-2-yl 3-(6-(((tert-butyldimethylsilyl)oxy)methyl)pyridin-3-yl)-2-((diphenylmethylene)amino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / diethyl ether; mineral oil / 1.25 h / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane; cyclohexane / 12 h / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / Inert atmosphere

4.1: Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾ / chloroform; toluene / 0.05 h / Cooling

4.2: Cooling

With Br^(1-)*C₃₇H₃₇N₂O⁽¹⁺⁾; sodium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; chloroform; cyclohexane; toluene; acetonitrile; mineral oil;
DOI:10.1021/ol202939g