3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione

Base Information

Chemical Name:3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione
CAS No.:1309444-74-3
Molecular Formula:C₁₄H₁₅ClN₂O₂S
Molecular Weight:310.804
Hs Code.:

Synonyms:3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione

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Chemical Property of 3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione

Chemical Property:

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Technology Process of 3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione

There total 4 articles about 3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₃ClN₂O₄S

: 1309444-74-3
3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.10.031

Reference yield:

: 15851-87-3
5-(4-chlorobenzylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1309444-74-3
3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; acetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: piperidine / methanol / 20 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / Inert atmosphere

With piperidine; hydrogenchloride; sodium tetrahydroborate; acetic acid; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; 2.1: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2011.10.031

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1309444-74-3
3-(2-aminoethyl)-5-(3-(4-chlorophenyl)propylidene)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: piperidine / ethanol / 5 h / Reflux; Inert atmosphere

2.1: sodium tetrahydroborate; acetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: piperidine / methanol / 20 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / Inert atmosphere

With piperidine; hydrogenchloride; sodium tetrahydroborate; acetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; 3.1: Knoevenagel condensation;
DOI:10.1016/j.ejmech.2011.10.031