(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

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Chemical Name:(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate
CAS No.:1335386-89-4
Molecular Formula:C₃₃H₃₉N₃O₇S
Molecular Weight:621.755
Hs Code.:

Synonyms:(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

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Chemical Property of (S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

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Technology Process of (S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

There total 11 articles about (S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335387-28-4
C₂₆H₃₅IN₂O₇S

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1335386-89-4
(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

Guidance literature:: With palladium 10% on activated carbon; potassium carbonate; In ethanol; water; toluene; at 80 ℃; for 8h;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1335386-89-4
(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 12 steps

1: sodium iodate; sulfuric acid; iodine; acetic acid

2: thionyl chloride / methanol / Reflux

3: sodium hydrogencarbonate / tetrahydrofuran

4: N,N-diisopropylamido-magnesium bromide; magnesium chloride / tetrahydrofuran

5: hydrogenchloride / water

6: sodium tetrahydroborate / ethanol / -78 °C

7: potassium carbonate / methanol

8: ethanol

9: sodium hydrogencarbonate / dichloromethane; water

10: hydrogenchloride / 1,4-dioxane

11: bis(trichloromethyl) carbonate; triethylamine / dichloromethane

12: palladium 10% on activated carbon; potassium carbonate / ethanol; water; toluene / 8 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sodium iodate; bis(trichloromethyl) carbonate; sulfuric acid; palladium 10% on activated carbon; N,N-diisopropylamido-magnesium bromide; iodine; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; magnesium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 12: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037

Reference yield:

: 1335387-17-1
C₁₅H₁₉ClINO₃

: 1335386-89-4
(S)-tetrahydrofuran-3-yl ((2S,3R)-1-(3'-cyano-[1,1'-biphenyl]-4-yl)-3-hydroxy-4-(N-isobutyl-4-methoxyphenylsulfonamido)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / ethanol / -78 °C

2: potassium carbonate / methanol

3: ethanol

4: sodium hydrogencarbonate / dichloromethane; water

5: hydrogenchloride / 1,4-dioxane

6: bis(trichloromethyl) carbonate; triethylamine / dichloromethane

7: palladium 10% on activated carbon; potassium carbonate / ethanol; water; toluene / 8 h / 80 °C

With hydrogenchloride; sodium tetrahydroborate; bis(trichloromethyl) carbonate; palladium 10% on activated carbon; sodium hydrogencarbonate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 7: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.037