Technology Process of 5-butyl-2-(3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)phenylsulfonamido)benzoic acid
There total 10 articles about 5-butyl-2-(3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)phenylsulfonamido)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 5-butyl-2-(3-(4-(2-methoxyphenyl)piperazine-1-carbonyl)phenylsulfonamido)benzoate;
With
lithium hydroxide monohydrate;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 12h;
With
citric acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 100 °C / Inert atmosphere
2.1: hydrogenchloride / methanol / 2 h
3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C
3.2: 0 - 20 °C
4.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 12 h / 20 °C
With
hydrogenchloride; lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: bromine; acetic acid / 3 h / 0 - 80 °C / Inert atmosphere
2.1: 1-methyl-pyrrolidin-2-one / 3 h / 140 °C / Inert atmosphere
3.1: water; sulfuric acid; acetic acid / 3 h / 90 °C / Inert atmosphere
4.1: thionyl chloride / 3 h / 0 - 90 °C / Inert atmosphere
5.1: pyridine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 0 °C
6.2: 0 - 20 °C
7.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol / 12 h / 20 °C
With
pyridine; thionyl chloride; lithium hydroxide monohydrate; sulfuric acid; water; bromine; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide;
