4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

Base Information

Chemical Name:4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde
CAS No.:1290138-75-8
Molecular Formula:C₁₂H₁₀BrFN₂O₂
Molecular Weight:313.126
Hs Code.:

Synonyms:4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

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Chemical Property of 4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

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Technology Process of 4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

There total 1 articles about 4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290138-75-8
4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

Guidance literature:: With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 0.666667h;

With Dess-Martin periodane; In acetonitrile; at 20 ℃;

Reference yield: 89.0%

: 1290138-75-8
4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

: 1290138-65-6
4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

Guidance literature:: 4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde; With pyridine; hydroxylamine hydrochloride; In ethanol; at 110 ℃; for 0.05h; microwave irradiation;

With acetic anhydride; at 150 ℃; for 0.833333h; microwave irradiation;

Reference yield:

: 1290138-75-8
4-bromo-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbaldehyde

: 1290138-66-7
4-(2,4-dimethylthiophen-3-yl)-3-(2-fluoro-4-methoxyphenyl)-1-methyl-1H-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; pyridine / ethanol / 0.05 h / 110 °C / microwave irradiation

1.2: 0.83 h / 150 °C / microwave irradiation

2.1: tris-(o-tolyl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

With pyridine; hydroxylamine hydrochloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris-(o-tolyl)phosphine; In ethanol; N,N-dimethyl-formamide;