N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide

Base Information

• Chemical Name: N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide
• CAS No.: 1326579-51-4
• Molecular Formula: C₄₀H₄₆N₄O₁₀
• Molecular Weight: 742.826
• Mol file: 1326579-51-4.mol

Synonyms:N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide

Chemical Property of N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide

There total 6 articles about N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C22H28N2O6 → N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide (1326579-51-4)

Guidance literature:

C₂₂H₂₈N₂O₆; With potassium carbonate; In ethanol; at 20 ℃; for 0.5h;

2-halo-N-(4-methoxyphenyl)acetamide; In ethanol; for 10h; Reflux;

DOI:10.2174/157340611796150914

Reference yield:

C15H12BrClO3 (1233979-40-2) → N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide (1326579-51-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetrahydrofuran; dichloromethane / 2 h / 20 °C / Cooling with ice

2.1: copper / N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4.1: potassium carbonate / ethanol / 0.5 h / 20 °C

4.2: 10 h / Reflux

With palladium 10% on activated carbon; hydrogen; copper; potassium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 2.1: Ullmann condensation;

DOI:10.2174/157340611796150914

Reference yield:

3-(benzyloxy)-2-bromo-4-methoxybenzoic acid (135586-17-3) → N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide (1326579-51-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.1: tetrahydrofuran; dichloromethane / 2 h / 20 °C / Cooling with ice

3.1: copper / N,N-dimethyl-formamide / 4 h / Inert atmosphere; Reflux

4.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

5.1: potassium carbonate / ethanol / 0.5 h / 20 °C

5.2: 10 h / Reflux

With thionyl chloride; palladium 10% on activated carbon; hydrogen; copper; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Ullmann condensation;

DOI:10.2174/157340611796150914

upstream raw materials:

C₁₅H₁₂BrClO₃

C₁₈H₂₀BrNO₃

2-bromoisovanillin

3-(benzyloxy)-2-bromo-4-methoxybenzoic acid