(R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol

Base Information

Chemical Name:(R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol
CAS No.:405116-14-5
Molecular Formula:C₂₅H₃₆O₅Si
Molecular Weight:444.643
Hs Code.:

Synonyms:(R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol

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Chemical Property of (R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol

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Technology Process of (R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol

There total 7 articles about (R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (R)-2-benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethyl ester

: 405116-14-5
(R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol

Guidance literature:: With sodium methylate; In methanol; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4020(01)01074-2

Reference yield:

: 18685-18-2,22331-21-1,23885-38-3,40982-92-1,65451-98-1,101475-83-6,134275-38-0,145625-96-3
3-O-benzyl-1,2:5,6-di-O-isopropylidene-D-glucofuranose

: 405116-14-5
(R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / 1N H₂SO₄ / dioxane / 70 °C

2: 85 percent / CSA / dimethylformamide / 8 h / 25 °C

3: 98 percent / Pb(OAc)4 / ethyl acetate / 0.5 h / 0 °C

4: 56 percent / NaBH₄ / methanol / 0.5 h / 0 °C

5: 76 percent / pyridine / 3 h / 0 - 20 °C

6: 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

7: 4.5 g / MeONa / methanol / 0.5 h / 0 °C

With pyridine; 2,6-dimethylpyridine; lead(IV) acetate; sodium tetrahydroborate; sulfuric acid; camphor-10-sulfonic acid; sodium methylate; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)01074-2

Reference yield:

: 65877-63-6,97590-76-6,99396-09-5,5531-09-9
3-O-benzyl-D-glucopyranose

: 405116-14-5
(R)-2-Benzyloxy-2-[(2R,4S,5R)-5-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-[1,3]dioxan-4-yl]-ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / CSA / dimethylformamide / 8 h / 25 °C

2: 98 percent / Pb(OAc)4 / ethyl acetate / 0.5 h / 0 °C

3: 56 percent / NaBH₄ / methanol / 0.5 h / 0 °C

4: 76 percent / pyridine / 3 h / 0 - 20 °C

5: 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

6: 4.5 g / MeONa / methanol / 0.5 h / 0 °C

With pyridine; 2,6-dimethylpyridine; lead(IV) acetate; sodium tetrahydroborate; camphor-10-sulfonic acid; sodium methylate; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)01074-2