4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

Base Information

Chemical Name:4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid
CAS No.:754954-61-5
Molecular Formula:C₃₆H₄₄N₄O₆
Molecular Weight:628.769
Hs Code.:

4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

Synonyms:4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

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Chemical Property of 4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

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Technology Process of 4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

There total 6 articles about 4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 754162-70-4
4-[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid benzyl ester

: 754954-61-5
4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In water; acetonitrile; for 24h; under 2068.6 Torr; Yield given; Ambient temperature;
DOI:10.1002/hlca.19970800421

Reference yield:

: 145485-77-4
3-t-butoxy-carbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide

: 754954-61-5
4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

3: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

4: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

5: PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

6: H₂ / Pd/C / acetonitrile; H₂O / 24 h / 2068.6 Torr / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.19970800421

Reference yield:

: 145486-32-4
3-amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide

: 754954-61-5
4-[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

2: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

3: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

4: PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

5: H₂ / Pd/C / acetonitrile; H₂O / 24 h / 2068.6 Torr / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.19970800421