4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

Base Information

Chemical Name:4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile
CAS No.:1372195-58-8
Molecular Formula:C₂₁H₂₁NO₃
Molecular Weight:335.403
Hs Code.:

Synonyms:4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

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Chemical Property of 4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

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Technology Process of 4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

There total 5 articles about 4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372195-57-7
((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)boronic acid

: 767-00-0
4-cyanophenol

: 1372195-58-8
4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

Guidance literature:: With oxygen; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1372195-53-3
2-(((S)-4-bromo-2,3-dihydro-1H-inden-1-yl)oxy)tetrahydro-2H-pyran

: 1372195-58-8
4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 3 h / Reflux

2: water / ethyl acetate / 16 h / 20 °C

3: copper diacetate; triethylamine; oxygen / dichloromethane / 72 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; oxygen; potassium acetate; copper diacetate; triethylamine; In 1,4-dioxane; dichloromethane; ethyl acetate;

Reference yield:

: 1372195-55-5
5,5-dimethyl-2-((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)-1,3,2-dioxaborinane

: 1372195-58-8
4-(((1S)-1-((tetrahydro-2H-pyran-2-yl)oxy)-2,3-dihydro-1H-inden-4-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: water / ethyl acetate / 16 h / 20 °C

2: copper diacetate; triethylamine; oxygen / dichloromethane / 72 h / 20 °C

With water; oxygen; copper diacetate; triethylamine; In dichloromethane; ethyl acetate;