N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide

Base Information

Chemical Name:N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide
CAS No.:1170231-80-7
Molecular Formula:C₂₁H₃₀N₂O₅S
Molecular Weight:422.546
Hs Code.:

Synonyms:N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide

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Chemical Property of N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide

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Technology Process of N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide

There total 7 articles about N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 110238-61-4
O-(cyclohexylmethyl)hydroxylamine

: 6633-95-0
6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)hexanesulfonyl chloride

: 1170231-80-7
N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide

Guidance literature:: O-(cyclohexylmethyl)hydroxylamine; With triethylamine; In dichloromethane; for 2h; Cooling with ice;

6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)hexanesulfonyl chloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jm4009949

Reference yield:

: sodium 6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonate

: 1170231-80-7
N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: phosphorus pentachloride / toluene

2.1: triethylamine / dichloromethane / 2 h / Cooling with ice

2.2: 20 °C

With phosphorus pentachloride; triethylamine; In dichloromethane; toluene;
DOI:10.1021/jm4009949

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1170231-80-7
N-(cyclohexylmethoxy)-6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.17 h / 20 - 45 °C

1.2: 1.5 h / 85 - 90 °C

2.1: hydrazine hydrate / methanol; dichloromethane / 1.5 h / 50 °C

3.1: triethylamine / dichloromethane / 2 h / Cooling with ice

3.2: 20 °C

With potassium carbonate; hydrazine hydrate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm4009949