R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol

Base Information

Chemical Name:R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol
CAS No.:151091-50-8
Molecular Formula:C₃₄H₄₃NO₃
Molecular Weight:513.72
Hs Code.:

Synonyms:R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol

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Chemical Property of R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol

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Technology Process of R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol

There total 4 articles about R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 115-46-8
C₁₈H₂₁NO

: 151091-48-4
R-(+)-4-chloro-1-<4-(1,1-dimethylethyl)phenyl>-1-butanol acetate

: 151091-50-8
R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 18h;
DOI:10.1021/jm5010682

Reference yield:

: 151091-53-1
R-(+)-4-chloro-1-<4-(1,1-dimethylethyl)phenyl>-1-butanol

: 151091-50-8
R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / diethyl ether / 2 h / Ambient temperature

2: NaI / acetone / 6 h / Heating

3: K₂CO₃ / butan-2-one / Heating

With potassium carbonate; triethylamine; sodium iodide; In diethyl ether; acetone; butanone;
DOI:10.1016/0223-5234(93)90009-4

Reference yield:

: 43076-61-5
4'-tert-butyl-4-chlorobutyrophenone

: 151091-50-8
R-(+)-1-<4-acetoxy-4-<4-(1,1-dimethylethyl)phenyl>butyl>-α,α,-diphenyl-4-piperidinomethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / (+)diisopinocampheylchloroborane / tetrahydrofuran / 7 h / 25 °C

2: 100 percent / Et₃N / diethyl ether / 2 h / Ambient temperature

3: NaI / acetone / 6 h / Heating

4: K₂CO₃ / butan-2-one / Heating

With potassium carbonate; triethylamine; B-chlorodiisopinocampheylborane; sodium iodide; In tetrahydrofuran; diethyl ether; acetone; butanone;
DOI:10.1016/0223-5234(93)90009-4