(2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one

Base Information

Chemical Name:(2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one
CAS No.:180318-98-3
Molecular Formula:C₁₈H₃₂N₂O₃
Molecular Weight:324.464
Hs Code.:

Synonyms:(2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one

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Chemical Property of (2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one

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Technology Process of (2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one

There total 4 articles about (2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 180471-21-0
(2S,5S)-2-tert-Butyl-5-cyclohex-1-enylmethyl-3-ethoxycarbonylmethyl-4-oxo-imidazolidine-1-carboxylic acid benzyl ester

: 180318-98-3
(2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; Ambient temperature;

Reference yield:

: 32273-16-8
2-tert-butyl-imidazolidin-4-one

: 180318-98-3
(2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 4 °C

2: 67 percent / BuLi / tetrahydrofuran; hexane / Ambient temperature

3: LDA / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 20 h; -78 to -38 deg C, 1.5 h

4: 95 percent / H₂ / Pd/C / ethyl acetate / Ambient temperature

With n-butyllithium; hydrogen; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;

Reference yield:

: 154261-48-0
2-tert-Butyl-4-oxo-imidazolidine-1-carboxylic acid benzyl ester

: 180318-98-3
(2R,5S)-2-tert-Butyl-5-(cyclohexylmethyl)-3-<(ethoxycarbonyl)methyl>imidazolidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / BuLi / tetrahydrofuran; hexane / Ambient temperature

2: LDA / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C, 20 h; -78 to -38 deg C, 1.5 h

3: 95 percent / H₂ / Pd/C / ethyl acetate / Ambient temperature

With n-butyllithium; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate;