[5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

Base Information

Chemical Name:[5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester
CAS No.:467253-70-9
Molecular Formula:C₃₇H₄₃N₆O₆P
Molecular Weight:698.759
Hs Code.:

[5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

Synonyms:[5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

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Chemical Property of [5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

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Technology Process of [5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

There total 7 articles about [5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182211-08-1
(1S)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethylphosphinic acid

: 467253-70-9
[5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: TMS-Cl; i-Pr₂NEt / CH₂Cl₂

2: EDCI / CH₂Cl₂

3: t-BuOK / 1,2-dimethoxy-ethane

4: TFA / CH₂Cl₂

5: toluene / 4 h / Heating

6: 1,1'-carbonyldiimidazole / tetrahydrofuran

With chloro-trimethyl-silane; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1016/S0040-4039(02)00957-7

Reference yield:

: 467253-77-6
5-Azido-2-[((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-pentanoic acid

: 467253-70-9
[5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / tetrahydrofuran

With 1,1'-carbonyldiimidazole; In tetrahydrofuran;
DOI:10.1016/S0040-4039(02)00957-7

Reference yield:

: 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid di-tert-butyl ester

: 467253-70-9
[5-Azido-2-((S)-1-methylcarbamoyl-2-naphthalen-2-yl-ethylcarbamoyl)-pentyl]-((S)-1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: EDCI / CH₂Cl₂

2: t-BuOK / 1,2-dimethoxy-ethane

3: TFA / CH₂Cl₂

4: toluene / 4 h / Heating

5: 1,1'-carbonyldiimidazole / tetrahydrofuran

With potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; toluene;
DOI:10.1016/S0040-4039(02)00957-7