(S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

Base Information

Chemical Name:(S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide
CAS No.:1312946-52-3
Molecular Formula:C₂₃H₂₂N₄O₂
Molecular Weight:386.453
Hs Code.:

Synonyms:(S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

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Chemical Property of (S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

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Technology Process of (S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

There total 4 articles about (S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1312949-14-6
2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)acetic acid

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1312946-52-3
(S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

Guidance literature:: 2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)acetic acid; With benzotriazol-1-ol; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

(S)-1-phenyl-ethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 65-85-0,8013-63-6
benzoic acid

: 1312946-52-3
(S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 4 h / 20 °C

2.1: n-butyllithium; 1,4-diaza-bicyclo[2.2.2]octane / hexane; tetrahydrofuran / -78 °C

2.2: 1 h

3.1: methanol / 4 h / 90 °C

4.1: sodium hydroxide / water; dimethyl sulfoxide / 10 h / 100 °C

4.2: 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Cooling with ice

5.2: 2 h / 20 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

7.1: diisopropyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

7.2: 20 °C

With 4-methyl-morpholine; 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1312949-13-5
ethyl 2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)acetate

: 1312946-52-3
(S)-2-(1-methyl-3-phenyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy)-N-(1-phenylethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 6 h / 20 °C

2.1: diisopropyl-carbodiimide; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

2.2: 20 °C

With water; benzotriazol-1-ol; lithium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;