(S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid

Base Information

• Chemical Name: (S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid
• CAS No.: 906644-74-4
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.375
• Mol file: 906644-74-4.mol

Synonyms:(S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid

Chemical Property of (S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid

There total 1 articles about (S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid methyl ester → (S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid (906644-74-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.tetasy.2006.04.029

Reference yield:

(S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid (906644-74-4) → (2S,2aR,2bR,3S,6S)-6-Methyl-2-phenoxy-3,4-diphenyl-2,2a,2b,3,4,6-hexahydro-4,5,6a-triaza-cyclobuta[a]pentalen-1-one

Guidance literature:

Multi-step reaction with 4 steps

1: oxalyl chloride

2: 86 percent / triphenylphosphine; carbon tetrachloride

3: 76 percent / silver(I) carbonate / dioxane / 24 h / 50 °C

With tetrachloromethane; oxalyl dichloride; triphenylphosphine; silver carbonate; In 1,4-dioxane;

DOI:10.1016/j.tetasy.2006.04.029

Reference yield:

(S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid (906644-74-4) → (S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionyl chloride

Guidance literature:

With oxalyl dichloride;

DOI:10.1016/j.tetasy.2006.04.029

Downstream raw materials:

(S)-2-[(3S,4R)-2-Oxo-3-phenoxy-4-((E)-styryl)-azetidin-1-yl]-propionic acid N'-phenyl-hydrazide