(S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

Base Information

Chemical Name:(S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate
CAS No.:112398-33-1
Molecular Formula:C₂₂H₃₀O₅SSi
Molecular Weight:434.629
Hs Code.:

Synonyms:(S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

Chemical Property:

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Technology Process of (S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

There total 3 articles about (S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 112373-72-5
(S)-(E)-2-(p-Toluenesulfinyl)vinyl methanesulfonate

: 112373-74-7
Diethyl 2-<3-(trimethylsilyl)prop-2-ynyl>malonate

: 112398-33-1
(S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1.) r.t., 1 h, 2.) r.t., 12 h;
DOI:10.1021/jo00090a042

Reference yield:

: 5056-07-5
(S)-methyl p-tolyl sulfoxide

: 112398-33-1
(S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

Guidance literature:: Multi-step reaction with 2 steps

2: 56 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 12 h

With sodium hydride; In tetrahydrofuran;
DOI:10.1021/jo00090a042

Reference yield:

: 112373-74-7
Diethyl 2-<3-(trimethylsilyl)prop-2-ynyl>malonate

: (S)-(E)-2-Iodovinyl p-tolyl sulfoxide

: 112398-33-1
(S)-(E)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

: (S)-(Z)-Diethyl 2-<2-(toluenesulfinyl)vinyl>-2-<3-(trimethylsilyl)prop-2-ynyl>malonate

Guidance literature:: With sodium hydride; In tetrahydrofuran; Yield given. Yields of byproduct given. Title compound not separated from byproducts; 1.) r.t., 1 h, 2.) 0 deg C to r.t., 12 h;
DOI:10.1021/jo00090a042