methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate

Base Information

Chemical Name:methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate
CAS No.:1610671-49-2
Molecular Formula:C₁₆H₁₁F₃N₄O₃
Molecular Weight:364.284
Hs Code.:

Synonyms:methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate

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Chemical Property of methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate

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Technology Process of methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate

There total 1 articles about methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1607830-93-2
methyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate

: 1548-13-6
p-trifluoromethyl-phenylisocyanate

: 1610671-49-2
methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate

Guidance literature:: methyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2.5h;

p-trifluoromethyl-phenylisocyanate; In tetrahydrofuran; at -78 ℃; for 3h;

Reference yield:

: 1610671-49-2
methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate

: 1610671-50-5
3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

Guidance literature:: methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With oxalyl dichloride; N,N-dimethyl-formamide;

Reference yield:

: 1610671-49-2
methyl3-((4-(trifluoromethyl)phenyl)carbamoyl)imidazo[1,2-a]pyrazine-6-carboxylate

: 1610671-48-1
6-N-(6-chloropyridin-3-yl)-6-N-methyl-3-N-[4-(trifluoromethyl)phenyl]imidazo[1,2-a]pyrazine-3,6-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; water / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 6 h / 20 °C

With N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;