1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride

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Chemical Name:1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride
CAS No.:1416216-01-7
Molecular Formula:C₃₁H₃₃FN₆O₃*ClH
Molecular Weight:593.101
Hs Code.:

Synonyms:1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride

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Chemical Property of 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride

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Technology Process of 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride

There total 6 articles about 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

: 945614-12-0
1-(3-(tertbutyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea

: 1416216-01-7
1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃; Concentration; Solvent;

Reference yield: 92.3%

: 2-(5-(2-(aminomethyl)-4-fluorophenoxy)-1H-indazol-1-yl)ethanol

: 285984-47-6
[5-tert-butyl-2-(4-methylphenyl)-2H-pyrazol-3-yl]carbamic acid phenyl ester

: 1416216-01-7
1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride

Guidance literature:: 2-(5-(2-(aminomethyl)-4-fluorophenoxy)-1H-indazol-1-yl)ethanol; [5-tert-butyl-2-(4-methylphenyl)-2H-pyrazol-3-yl]carbamic acid phenyl ester; In isopropyl alcohol; at 35 - 40 ℃; for 5h; Large scale;

With hydrogenchloride; In water; isopropyl alcohol; at 18 - 23 ℃; Large scale;

Reference yield:

: 2973-80-0
2-bromo-5-hydroxybenzaldehyde

: 1416216-01-7
1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 19 h / 80 °C / Inert atmosphere

2.1: N,N-dimethyl acetamide / 0.75 h / 120 °C

3.1: potassium carbonate; copper (II) carbonate hydroxide / N,N-dimethyl acetamide / 3.5 h / 120 °C

4.1: ammonia; hydrogen / methanol / 5 h / 100 °C / 10343.2 Torr

5.1: isopropyl alcohol / 5 h / 35 - 40 °C / Large scale

5.2: 18 - 23 °C / Large scale

With copper (II) carbonate hydroxide; ammonia; hydrogen; potassium carbonate; In methanol; N,N-dimethyl acetamide; dimethyl sulfoxide; isopropyl alcohol;