(1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane
CAS No.:676126-76-4
Molecular Formula:C₄₃H₃₆O₆
Molecular Weight:648.755
Hs Code.:

Synonyms:(1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

Suppliers and Price of (1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

There total 11 articles about (1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 676126-74-2
(1R,3S,4S,7R)-7-hydroxy-1-hydroxymethyl-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

: 676126-76-4
(1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: With pyridine; at 20 ℃; for 12h;
DOI:10.1039/b310719a

Reference yield:

: methyl 2-O-acetyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-3-O-(p-methoxybenzyl)-α,β-L-erythro-pentofuranoside

: 676126-76-4
(1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 11 steps

1.1: ammonia / methanol / 24 h / 20 °C

1.2: NaH / dimethylformamide / 12 h / 20 °C

2.1: 18-crown-6 / dioxane / 12 h / Heating

3.1: ammonia / methanol / 12 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

4.2: tetrabutylammonium iodide / tetrahydrofuran / 36 h / 20 °C

5.1: aq. AcOH / 12 h / 20 °C

6.1: magnesium; iodine / tetrahydrofuran / 1 h / 40 °C

6.2: 71 percent / tetrahydrofuran / 12 h / 20 °C

7.1: pyridinium dichromate; 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

8.1: 246 mg / aq. NaBH₄ / tetrahydrofuran / 0.5 h / 20 °C

9.1: 88 percent / N,N,N',N'-tetramethylazodicarboxamide; PBu₃ / benzene / 12 h / 20 °C

10.1: 52 percent / DDQ; water / CH₂Cl₂ / 4 h / 20 °C

11.1: 54 percent / pyridine / 12 h / 20 °C

With pyridine; sodium tetrahydroborate; dipyridinium dichromate; 18-crown-6 ether; tributylphosphine; 3 A molecular sieve; diamide; ammonia; water; iodine; sodium hydride; magnesium; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; benzene; 6.2: Grignard addition / 9.1: Mitsunobu reaction;
DOI:10.1039/b310719a

Reference yield:

: (1R,3RS,4S,7R)-1-hydroxymethyl-3-methoxy-7-(p-methoxybenzyloxy)-2,5-dioxabicyclo[2.2.1]heptane

: 676126-76-4
(1S,3S,4S,7R)-1-(4,4'-dimethoxytrityloxymethyl)-7-hydroxy-3-(1-pyrenyl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran / 0.25 h / 20 °C

1.2: tetrabutylammonium iodide / tetrahydrofuran / 36 h / 20 °C

2.1: aq. AcOH / 12 h / 20 °C

3.1: magnesium; iodine / tetrahydrofuran / 1 h / 40 °C

3.2: 71 percent / tetrahydrofuran / 12 h / 20 °C

4.1: pyridinium dichromate; 3 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

5.1: 246 mg / aq. NaBH₄ / tetrahydrofuran / 0.5 h / 20 °C

6.1: 88 percent / N,N,N',N'-tetramethylazodicarboxamide; PBu₃ / benzene / 12 h / 20 °C

7.1: 52 percent / DDQ; water / CH₂Cl₂ / 4 h / 20 °C

8.1: 54 percent / pyridine / 12 h / 20 °C

With pyridine; sodium tetrahydroborate; dipyridinium dichromate; tributylphosphine; 3 A molecular sieve; diamide; water; iodine; sodium hydride; magnesium; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; benzene; 3.2: Grignard addition / 6.1: Mitsunobu reaction;
DOI:10.1039/b310719a