[1S-[1α(βS,δS),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

Base Information

Chemical Name:[1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt
CAS No.:135716-30-2
Molecular Formula:C₂₄H₄₄NO₅*Li
Molecular Weight:433.558
Hs Code.:

Synonyms:[1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

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Chemical Property of [1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

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Technology Process of [1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

There total 15 articles about [1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: N-[[2-[2-(Tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)-ethyl]-3-methyl-6-propylcyclohexyl]methyl]-2,2-dimethylbutanamide

: 135716-30-2
[1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

Guidance literature:: With LiOH; In 1,4-dioxane; water;

Reference yield:

: 135716-23-3
[(1S,2S,3S,6R)-2-(2-{(4R,6S)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-6-propyl-cyclohexyl]-methanol

: 135716-30-2
[1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / CH₂Cl₂ / 0 °C

2: NaN₃ / dimethylformamide / 50 °C

3: H₂, Et₃N / 10percent Pd-C / ethanol; methanol

4: 76 percent / DMAP / pyridine

5: n-Bu₄NF / tetrahydrofuran

6: 1) Dess-Martin periodinane, 2) 1.0 aq. KMnO₄, 5percent NaH₂PO₄ / t-BuOH, CH₂Cl₂

7: 78 percent / diethyl ether / 0 °C

8: 95 percent / aq. HF / acetonitrile

9: 0.1n LiOH / dioxane

With dmap; lithium hydroxide; potassium permanganate; sodium dihydrogenphosphate; sodium azide; hydrogen fluoride; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4039(91)80587-V

Reference yield:

: 135716-19-7
[(1S,2S,3S,6S)-6-Allyl-2-(2-{(4R,6S)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-3-methyl-cyclohexyl]-methanol

: 135716-30-2
[1S-[1α(βS*,δS*),2β,3α,6α]]-2-[[(2,2-Dimethyl-1-oxobutyl)amino]methyl]-β,δ-dihydroxy-6-methyl-3-propylcyclohexaneheptanoic acid, monolithium salt

Guidance literature:: Multi-step reaction with 10 steps

1: H₂ / 10percent Pd-C / methanol

2: Et₃N / CH₂Cl₂ / 0 °C

3: NaN₃ / dimethylformamide / 50 °C

4: H₂, Et₃N / 10percent Pd-C / ethanol; methanol

5: 76 percent / DMAP / pyridine

6: n-Bu₄NF / tetrahydrofuran

7: 1) Dess-Martin periodinane, 2) 1.0 aq. KMnO₄, 5percent NaH₂PO₄ / t-BuOH, CH₂Cl₂

8: 78 percent / diethyl ether / 0 °C

9: 95 percent / aq. HF / acetonitrile

10: 0.1n LiOH / dioxane

With dmap; lithium hydroxide; potassium permanganate; sodium dihydrogenphosphate; sodium azide; hydrogen fluoride; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/0040-4039(91)80587-V