Technology Process of 2-(4-bromophenyl)-1-(4-chlorophenyl)-2-phenylethanone
There total 3 articles about 2-(4-bromophenyl)-1-(4-chlorophenyl)-2-phenylethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; caesium carbonate;
In
tetrahydrofuran;
at 25 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol102626p
- Guidance literature:
-
Multi-step reaction with 2 steps
1: Acetyl bromide / benzene / 6 h / 20 °C / Inert atmosphere
2: 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; caesium carbonate / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
With
Acetyl bromide; 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; caesium carbonate;
In
tetrahydrofuran; benzene;
DOI:10.1021/ol102626p
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C / Inert atmosphere
2: Acetyl bromide / benzene / 6 h / 20 °C / Inert atmosphere
3: 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; caesium carbonate / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
With
sodium tetrahydroborate; Acetyl bromide; 3-(2,4,6-trimethyl-phenyl)-5,6,7,8-tetrahydro-4H-cycloheptathiazol-3-ium perchlorate; caesium carbonate;
In
tetrahydrofuran; methanol; benzene;
DOI:10.1021/ol102626p