methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

Base Information

Chemical Name:methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate
CAS No.:856168-80-4
Molecular Formula:C₂₃H₁₉FN₂O₂S
Molecular Weight:406.48
Hs Code.:

Synonyms:methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

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Technology Process of methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

There total 1 articles about methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214210-21-6
3-cyano-4-fluorophenylboronic acid

: 856168-78-0
methyl (R)-(5-(5-bromo-thiazol-2-yl)-4-methyl-indan-1-yl)acetate

: 856168-79-1
ethyl (R)-(5-(5-bromo-thiazol-2-yl)-4-methyl-indan-1-yl)acetate

: 856168-80-4
methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

: 856168-81-5
ethyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 80 ℃; for 1.5h;

Reference yield:

: 856168-80-4
methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

: 856168-81-5
ethyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate

: 67-63-0,8013-70-5
isopropyl alcohol

: (R)-(5-(5-(3-cyano-4-isopropoxyphenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetic acid

Guidance literature:: methyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate; ethyl (R)-(5-(5-(3-cyano-4-fluorophenyl)thiazol-2-yl)-4-methyl-indan-1-yl)acetate; isopropyl alcohol; With sodium hydride; In tetrahydrofuran; for 2h; Heating / reflux;

With citric acid; In tetrahydrofuran; water; ethyl acetate;