4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid

Base Information

Chemical Name:4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid
CAS No.:1114591-62-6
Molecular Formula:C₂₂H₂₈N₄O₅S
Molecular Weight:460.554
Hs Code.:

Synonyms:4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid

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Chemical Property of 4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid

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Technology Process of 4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid

There total 9 articles about 4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1114592-57-2
ethyl 4-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidine-4-carboxamido)phenylsulfonyl)butanoate

: 1114591-62-6
4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid

Guidance literature:: ethyl 4-(4-(6-((cyclopropylmethyl)(propyl)amino)pyrimidine-4-carboxamido)phenylsulfonyl)butanoate; With sodium hydroxide; water; In ethanol; at 20 ℃; for 18h;

With hydrogenchloride; In ethanol; water; pH=3;

Reference yield:

: 1114592-37-8
ethyl 4-(4-nitrophenylsulfonyl)butanoate

: 1114591-62-6
4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethanol / 18 h

2.1: triethylamine; methyl chloroformate / dichloromethane / 0.5 h / 0 °C

2.2: 1.08 h / 0 - 20 °C

3.1: sodium hydroxide; water / ethanol / 18 h / 20 °C

3.2: pH 3

With sodium hydroxide; water; hydrogen; triethylamine; methyl chloroformate; 5%-palladium/activated carbon; In ethanol; dichloromethane;

Reference yield:

: 1114592-15-2
methyl 2-chloro-6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylate

: 1114591-62-6
4-({4-[({6-[(cyclopropylmethyl)(propyl)amino]pyrimidin-4-yl}carbonyl)amino]phenyl}sulfonyl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium formate / palladium on activated charcoal / water; isopropyl alcohol / 1 h / 20 °C

2.1: lithium hydroxide; water / tetrahydrofuran; ethanol / 1 h / 20 °C

2.2: pH 5

3.1: triethylamine; methyl chloroformate / dichloromethane / 0.5 h / 0 °C

3.2: 1.08 h / 0 - 20 °C

4.1: sodium hydroxide; water / ethanol / 18 h / 20 °C

4.2: pH 3

With lithium hydroxide; sodium hydroxide; water; ammonium formate; triethylamine; methyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; isopropyl alcohol;