ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Base Information

Chemical Name:ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate
CAS No.:1206124-19-7
Molecular Formula:C₂₄H₂₁F₆NO₃
Molecular Weight:485.426
Hs Code.:

Synonyms:ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

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Chemical Property of ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

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Technology Process of ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

There total 4 articles about ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206124-13-1
ethyl 2-(7-hydroxy-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

: 32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide

: 1206124-19-7
ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 191348-14-8
2-iodo-4-methoxylaniline

: 1206124-19-7
ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetraethoxy orthosilicate; pyridinium p-toluenesulfonate / N,N-dimethyl-formamide / 4 h / Heating

1.2: 3 h / 135 °C

2.1: boron tribromide / dichloromethane / 1.5 h / Cooling

3.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With tetraethoxy orthosilicate; pyridinium p-toluenesulfonate; boron tribromide; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml500389m

Reference yield:

: 20826-94-2
ethyl (2-oxocyclopentyl)acetate

: 1206124-19-7
ethyl 2-(7-(3,5-bis(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetraethoxy orthosilicate; pyridinium p-toluenesulfonate / N,N-dimethyl-formamide / 4 h / Heating

1.2: 3 h / 135 °C

2.1: boron tribromide / dichloromethane / 1.5 h / Cooling

3.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With tetraethoxy orthosilicate; pyridinium p-toluenesulfonate; boron tribromide; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml500389m