(+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Base Information

• Chemical Name: (+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine
• CAS No.: 889885-57-8
• Molecular Formula: C₄₂H₅₂N₅O₉P
• Molecular Weight: 801.877
• Mol file: 889885-57-8.mol

Synonyms:(+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property of (+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

There total 6 articles about (+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(+/-)-9-[(1-methyl)(3-phosphonomethoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-50-1) + Chloromethyl pivalate (18997-19-8) → (+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-57-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1080/15257770500268673

Reference yield:

9-[3-(tert-butyl-dimethyl-silanyloxy)-1-methyl-propyl]-9H-purin-6-ylamine (917240-78-9) → (+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-57-8)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 20 h / 70 °C

2: 1.97 g / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: NaH / dimethylformamide / 24 h / 20 °C

4: 760 mg / Et₃N; trimethylsilyliodide / dimethylformamide / 14 h / 20 °C

5: 47 percent / Et₃N / dimethylformamide / 72 h / 20 °C

With pyridine; trimethylsilyl iodide; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1080/15257770500268673

Reference yield:

(+/-)-9-[(1-methyl)(3-hydroxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-34-1) → (+/-)-9-[(1-methyl)(3-(di-tert-butylcarbonyloxymethylphosphono)methoxy)propyl]-N6-(4-monomethoxytrityl)-adenine (889885-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 24 h / 20 °C

2: 760 mg / Et₃N; trimethylsilyliodide / dimethylformamide / 14 h / 20 °C

3: 47 percent / Et₃N / dimethylformamide / 72 h / 20 °C

With trimethylsilyl iodide; sodium hydride; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1080/15257770500268673

upstream raw materials:

(+/-)-9-[(1-methyl)(3-phosphonomethoxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine

Chloromethyl pivalate

9-[3-(tert-butyl-dimethyl-silanyloxy)-1-methyl-propyl]-9H-purin-6-ylamine

(+/-)-9-[(1-methyl)(3-hydroxy)propyl]-N⁶-(4-monomethoxytrityl)-adenine